Chemoselective Covalent Coupling of Oligonucleotide Probes to Self-Assembled Monolayers
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چکیده
منابع مشابه
Chemoselective covalent coupling of oligonucleotide probes to self-assembled monolayers.
A chemoselective route to routinely and rapidly attach oligonucleotide probes to well-defined surfaces is presented. Cu(I) tris(benzyltriazolylmethyl)amine-catalyzed coupling of terminal acetylenes to azides on a self-assembled monolayer is used instead of traditional nucleophilic-electrophilic coupling reactions. The reaction proceeds well even in the presence of purposely introduced nucleophi...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 2005
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja051462l